Controlled trial of exposure and response prevention in obsessive-compulsive disorder

Br J Psychiatry. 1997 Aug:171:135-9. doi: 10.1192/bjp.171.2.135.

Abstract

Background: Exposure and response prevention is considered a treatment of choice for obsessive-compulsive disorder (OCD). Yet there have been very few randomised controlled trials employing credible placebo conditions. This study compares exposure and response prevention with a general anxiety management intervention.

Method: Eighteen patients meeting DSM-IV criteria for OCD were randomly assigned to either exposure and response prevention or anxiety management. Both treatments involved approximately 15 hours of therapy over a three-week period.

Results: There was a significant reduction in obsessive-compulsive symptoms following treatment with exposure and response prevention, while no change occurred in the control group. This was found to be statistically significant using a composite measure of OCD symptom severity, patient ratings of interference and therapist ratings of symptom severity.

Conclusions: These findings suggest that the symptom reductions associated with behaviour therapy for OCD are a result of the specific techniques of exposure and response prevention, rather than non-specific aspects of the therapy process. General anxiety management techniques are not effective in the treatment of OCD.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anxiety / therapy
  • Behavior Therapy / methods*
  • Female
  • Humans
  • Male
  • Observer Variation
  • Obsessive-Compulsive Disorder / therapy*
  • Psychiatric Status Rating Scales
  • Treatment Outcome