Trichomoniasis in a postmenopausal woman cured after discontinuation of estrogen replacement therapy

Sex Transm Dis. 1997 Oct;24(9):543-5. doi: 10.1097/00007435-199710000-00009.


Background: Epidemiologic and experimental data suggest that estrogen has a salutary effect on Trichomonas vaginalis.

Case: A metronidazole-allergic postmenopausal woman was cured of vaginal trichomoniasis in association with discontinuation of estrogen replacement therapy.

Conclusion: Hormonal manipulation should be studied for the management of women with trichomoniasis who are allergic to metronidazole or who are infected with metronidazole-resistant strains of Trichomonas vaginalis.

Publication types

  • Case Reports

MeSH terms

  • Antitrichomonal Agents / adverse effects
  • Drug Eruptions / etiology
  • Estrogen Replacement Therapy / adverse effects*
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Metronidazole / adverse effects
  • Middle Aged
  • Postmenopause*
  • Trichomonas Vaginitis / chemically induced*
  • Trichomonas Vaginitis / drug therapy
  • Vagina / drug effects


  • Antitrichomonal Agents
  • Metronidazole