Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract

Graefes Arch Clin Exp Ophthalmol. 1997 Sep;235(9):551-2. doi: 10.1007/BF00947082.

Abstract

Background: Experimental evidence suggests a role of endothelin-1 (ET) in the regulation of intraocular pressure (IOP).

Method: Therefore, in patients undergoing cataract surgery, ET-like immunoreactivity (ETIR) was measured by radioimmunoassay in pooled samples of aqueous humor of eyes with primary open-angle glaucoma (POAG) and normotensive eyes with cataract only.

Results: ETIR was significantly (P < 0.05) higher in patients with cataract and POAG (20.5 +/- 1.8 pg/ml, n = 12; preoperative IOP 21.4 +/- 1.1 mmHg, n = 33) than in patients with cataract only (15.8 +/- 1.6 pg/ml, n = 15; preoperative IOP 16.0 +/- 0.6 mmHg, n = 77).

Conclusion: This finding may indicate a role of ET in POAG or ocular antihypertensive treatment, and its relevance should be further investigated.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Topical
  • Adrenergic beta-Antagonists / administration & dosage
  • Adrenergic beta-Antagonists / therapeutic use
  • Aqueous Humor / metabolism*
  • Cataract / metabolism*
  • Cataract Extraction
  • Endothelin-1 / drug effects
  • Endothelin-1 / metabolism*
  • Glaucoma, Open-Angle / drug therapy
  • Glaucoma, Open-Angle / metabolism*
  • Glaucoma, Open-Angle / surgery
  • Humans
  • Intraocular Pressure / drug effects
  • Intraocular Pressure / physiology
  • Ophthalmic Solutions
  • Radioimmunoassay

Substances

  • Adrenergic beta-Antagonists
  • Endothelin-1
  • Ophthalmic Solutions