Oral administration of a unicellular green algae, Chlorella vulgaris, prevents stress-induced ulcer

Planta Med. 1997 Oct;63(5):465-6. doi: 10.1055/s-2006-957736.


Oral administration of dry powder of Chlorella vulgaris (CVP) showed clear prophylactic effects in water-immersion restraint stress-induced and in cysteamine-induced peptic ulcer models, but not in Shay's rat model. Drugs that enhance the protective factors of ulcer formation are effective in the first two models. CVP may prevent ulcer formation mainly through the "immune-brain-gut" axis and protection of gastric mucosa by its own characteristics.

Publication types

  • Letter

MeSH terms

  • Administration, Oral
  • Animals
  • Chlorella*
  • Cysteamine
  • Gastric Mucosa / pathology
  • Gastric Mucosa / physiopathology*
  • Histamine
  • Plants, Medicinal*
  • Rats
  • Restraint, Physical
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / physiopathology
  • Stomach Ulcer / prevention & control*
  • Stress, Psychological*


  • Cysteamine
  • Histamine