Programs for visualization in three-dimensional microscopy

Neuroimage. 1992 Aug;1(1):55-67. doi: 10.1016/1053-8119(92)90007-a.


Three-dimensional data representing biological structures can be derived using several methods, including serial section reconstruction, optical sectioning, and tomography. The investigation, comprehension, and communication of structural relationships to others is greatly facilitated by computer-based visualization procedures. We describe SYNU, a suite of programs developed for interactive investigation of three-dimensional structure and for the production of high-quality three-dimensional images and animations. We illustrate the capabilities of SYNU in applications to biological data obtained by confocal light microscopy, serial section, and high-resolution electron microscopy from investigations at the cellular, subcellular, and molecular levels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actin Cytoskeleton / pathology
  • Alzheimer Disease / pathology
  • Animals
  • Brain / pathology*
  • Brain Mapping*
  • Chickens
  • Dendrites / pathology
  • Humans
  • Image Processing, Computer-Assisted*
  • Microscopy, Confocal*
  • Microscopy, Electron*
  • Nuclear Envelope / pathology
  • Purkinje Cells / pathology
  • Software*
  • Synaptic Membranes / pathology