Benzoquinones inhibit the expression of inducible nitric oxide synthase gene

Biochem Biophys Res Commun. 1997 Oct 20;239(2):367-71. doi: 10.1006/bbrc.1997.7437.

Abstract

Benzoquinones inhibited the production of NO induced by LPS and gamma-IFN in C6 glia cells. The mechanistic studies showed that benzoquinones inhibited the expression of iNOS mRNA through inactivation of NF kappa B. Benzoquinones may be a useful candidate for the development of a drug to treat disease due to iNOS gene over-expression.

MeSH terms

  • Animals
  • Benzoquinones / pharmacology*
  • Gene Expression Regulation, Enzymologic / drug effects*
  • Genes / drug effects*
  • Neuroglia
  • Nitric Oxide Synthase / biosynthesis
  • Nitric Oxide Synthase / genetics*
  • RNA, Messenger / antagonists & inhibitors
  • Rats
  • Tumor Cells, Cultured

Substances

  • Benzoquinones
  • RNA, Messenger
  • Nitric Oxide Synthase