Structural and sequence-based classification of glycoside hydrolases

Curr Opin Struct Biol. 1997 Oct;7(5):637-44. doi: 10.1016/s0959-440x(97)80072-3.


The diversity of oligo- and polysaccharides provides an abundance of biological roles for these carbohydrates. The enzymes hydrolysing these compounds, the glycoside hydrolases, therefore mediate a wealth of biological functions. Glycoside hydrolases fall into a number of sequence-based families. The recent analysis of these families, coupled with the burgeoning number of 3D structures, provides a detailed insight into the structure, function and catalytic mechanism of these enzymes.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Carbohydrate Conformation
  • Glycoside Hydrolases / chemistry*
  • Glycoside Hydrolases / classification*
  • Glycoside Hydrolases / metabolism
  • Molecular Sequence Data
  • Protein Conformation
  • Sequence Homology, Amino Acid
  • Substrate Specificity


  • Glycoside Hydrolases