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. 1997 Oct 17;91(2):197-208.
doi: 10.1016/s0092-8674(00)80402-x.

Multiple Female Reproductive Failures in Cyclooxygenase 2-deficient Mice

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Multiple Female Reproductive Failures in Cyclooxygenase 2-deficient Mice

H Lim et al. Cell. .

Abstract

Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of prostaglandins (PGs) and exists in two isoforms, COX-1 and COX-2. In spite of long-standing speculation, definitive roles of PGs in various events of early pregnancy remain elusive. We demonstrate herein that the targeted disruption of COX-2, but not COX-1, in mice produces multiple failures in female reproductive processes that include ovulation, fertilization, implantation, and decidualization. Using multiple approaches, we conclude that these defects are the direct result of target organ-specific COX-2 deficiency but are not the result of deficiency of pituitary gonadotropins or ovarian steroid hormones, or reduced responsiveness of the target organs to their respective hormones.

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