Risk Factors for Alzheimer's Disease: A Case-Control Study

Neuroepidemiology. 1997;16(5):234-40. doi: 10.1159/000109692.

Abstract

The extent of current knowledge of risk factors for Alzheimer's disease (AD) is still limited. We conducted a case-control study of 98 AD patients and 98 age- and sex-matched controls. Light smoking had a decreased risk for AD (AD: 2.0%, controls: 21.4%, odds ratio = 0.10, p = 0.003), whereas daily smoking showed a trend to increase the risk for AD (AD: 45.9%, controls: 26.5%, odds ratio = 1.73, p = 0.08). After multivariable analyses factors associated with AD included the presence of apolipoprotein epsilon4 allele, and the duration of well water consumption.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / etiology
  • Alzheimer Disease / genetics*
  • Apolipoproteins E / genetics
  • Case-Control Studies
  • Female
  • Genotype
  • Hazardous Substances / adverse effects
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Smoking / adverse effects
  • Water / adverse effects

Substances

  • Apolipoproteins E
  • Hazardous Substances
  • Water