Prominent sensory ataxia in Guillain-Barré syndrome associated with IgG anti-GD1b antibody

J Neurol Sci. 1997 Oct 22;151(2):227-9. doi: 10.1016/s0022-510x(97)00136-6.


Sensitization with GD1b has been shown to cause sensory neuropathy in rabbit. A patient with chronic sensory-dominant polyneuropathy who had IgM antibody specifically to GD1b has been reported previously. This report describes the first patient with acute demyelinating polyneuropathy with prominent sensory symptoms who had a high titer of serum IgG anti-GD1b antibody. The serum reacted with neither GM1 nor with other b-series gangliosides (GD2, GD3, GT1b and GQ1b). Improvement in symptoms was coincident with decrease in IgG anti-GD1b antibody titer after plasmapheresis. This case supports the experimental results in rabbit suggesting that anti-GD1b antibody functions in the development of sensory ataxia.

Publication types

  • Case Reports

MeSH terms

  • Ataxia / complications*
  • Demyelinating Diseases / pathology
  • Demyelinating Diseases / physiopathology
  • Enzyme-Linked Immunosorbent Assay
  • Gangliosides / immunology*
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin G / immunology*
  • Male
  • Middle Aged
  • Polyradiculoneuropathy / complications*
  • Polyradiculoneuropathy / immunology*


  • Gangliosides
  • Immunoglobulin G
  • ganglioside, GD1b