Failed Nissen fundoplication in two patients who had persistent vomiting and eosinophilic esophagitis

J Pediatr Surg. 1997 Oct;32(10):1504-6. doi: 10.1016/s0022-3468(97)90577-7.


The following report describes two patients who had chronic symptoms of gastroesophageal reflux and persistent histological esophagitis, despite aggressive medical antireflux therapy, who continued to have esophagitis and remained symptomatic post antireflux surgery (Nissen fundoplication). Both patients demonstrated a severe eosinophilic esophagitis with normal gastric and duodenal histology before and after surgery. Postoperatively, each received the diagnosis of allergic enteritis and both responded clinically and histologically to oral corticosteroids and an elemental diet.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / therapeutic use
  • Child
  • Eosinophilia / complications*
  • Esophagitis / complications*
  • Esophagitis / drug therapy
  • Esophagitis / pathology
  • Female
  • Fundoplication / methods*
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / surgery*
  • Humans
  • Male
  • Methylprednisolone / therapeutic use
  • Severity of Illness Index
  • Treatment Failure
  • Vomiting / complications*


  • Anti-Inflammatory Agents
  • Methylprednisolone