Induction of HIV-1 specific mucosal immune responses by DNA vaccination

Scand J Immunol. 1997 Oct;46(4):326-30. doi: 10.1046/j.1365-3083.1997.d01-146.x.


DNA vaccination has been shown to induce immunity against several different pathogens including HIV-1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV-1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intranasal
  • Animals
  • Antigens, Viral / immunology
  • Epitopes / immunology
  • HIV Antibodies / biosynthesis*
  • HIV-1 / immunology*
  • Immunity, Mucosal
  • Immunoglobulin A / biosynthesis
  • Immunoglobulin G / biosynthesis
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Vaccines, DNA / administration & dosage
  • Vaccines, DNA / immunology*


  • Antigens, Viral
  • Epitopes
  • HIV Antibodies
  • Immunoglobulin A
  • Immunoglobulin G
  • Vaccines, DNA