Comparison of Fos Induced in Rat Brain by GLP-1 and Amylin

Regul Pept. 1997 Aug 29;71(3):171-4. doi: 10.1016/s0167-0115(97)01034-3.

Abstract

The patterns of Fos-like immunoreactivity (Fos-ir) in rat brain were compared following treatment of rats with two anorectic 'gut' peptides. Central administration of GLP-1 produced dose-related increases in Fos-ir in the area postrema (AP) and caudal nucleus of the solitary tract (cNTS) as well as strong activation in the lateral parabrachial nucleus (LPBE), hypothalamic paraventricular nucleus (PVN), bed nucleus of the stria terminalis (BNST) and central nucleus of the amygdala (CeA). At centrally-active doses, peripheral administration of GLP-1 did not induce Fos-ir in brain. In contrast, peripheral administration of amylin produced strong Fos-ir in the AP and cNTS, as well as the BNST and CeA, but not in the PVN. The common activation of the LPB-BNST-CeA by these and other previously-studied anorectics suggest this is an important circuit involved in satiety.

Publication types

  • Comparative Study

MeSH terms

  • Amyloid / pharmacology*
  • Angiotensin II / analogs & derivatives*
  • Angiotensin II / pharmacology
  • Animals
  • Bombesin / pharmacology
  • Brain / drug effects
  • Brain / metabolism*
  • Cholecystokinin / pharmacology
  • Glucagon / pharmacology*
  • Glucagon-Like Peptide 1
  • Islet Amyloid Polypeptide
  • Male
  • Oncogene Proteins v-fos / drug effects
  • Oncogene Proteins v-fos / immunology
  • Oncogene Proteins v-fos / metabolism*
  • Peptide Fragments / pharmacology*
  • Protein Precursors / pharmacology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Amyloid
  • Islet Amyloid Polypeptide
  • Oncogene Proteins v-fos
  • Peptide Fragments
  • Protein Precursors
  • Angiotensin II
  • angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-
  • Glucagon-Like Peptide 1
  • Glucagon
  • Cholecystokinin
  • Bombesin