Leptin Interacts With Glucagon-Like peptide-1 Neurons to Reduce Food Intake and Body Weight in Rodents

FEBS Lett. 1997 Sep 29;415(2):134-8. doi: 10.1016/s0014-5793(97)01103-4.

Abstract

The adipose tissue hormone, leptin, and the neuropeptide glucagon-like peptide-1 (7-36) amide (GLP-1) both reduce food intake and body weight in rodents. Using dual in situ hybridization, long isoform leptin receptor (OB-Rb) was localized to GLP-1 neurons originating in the nucleus of the solitary tract. ICV injection of the specific GLP-1 receptor antagonist, exendin(9-39), at the onset of dark phase, did not affect feeding in saline pre-treated controls, but blocked the reduction in food intake and body weight of leptin pre-treated rats. These findings suggest that GLP-1 neurons are a potential target for leptin in its control of feeding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • DNA Probes
  • Eating* / drug effects
  • Gene Expression
  • Glucagon / analysis
  • Glucagon / genetics
  • Glucagon / metabolism*
  • Glucagon-Like Peptide 1
  • In Situ Hybridization
  • Leptin
  • Light
  • Male
  • Mice
  • Mice, Inbred Strains
  • Neurons / chemistry
  • Neurons / metabolism*
  • Peptide Fragments / metabolism*
  • Peptide Fragments / pharmacology
  • Proglucagon
  • Protein Precursors / analysis
  • Protein Precursors / genetics
  • Protein Precursors / metabolism*
  • Proteins / antagonists & inhibitors
  • Proteins / metabolism*
  • Proteins / pharmacology
  • RNA, Messenger / analysis
  • Rats
  • Rats, Wistar
  • Receptors, Cell Surface*
  • Receptors, Leptin
  • Solitary Nucleus / cytology*
  • Solitary Nucleus / metabolism

Substances

  • Carrier Proteins
  • DNA Probes
  • Leptin
  • Peptide Fragments
  • Protein Precursors
  • Proteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • Receptors, Leptin
  • leptin receptor, mouse
  • exendin (9-39)
  • Proglucagon
  • Glucagon-Like Peptide 1
  • Glucagon