Moderate metabolic acidosis and its effects on nutritional parameters in hemodialysis patients

Clin Nephrol. 1997 Oct;48(4):238-40.


We screened the laboratory data of all of our chronic hemodialysis patients to identify 2 groups: 1) those with a pre-dialysis total CO2 concentration equal or less than 21 mEq/l (group A) and 2) those with a pre-dialysis total CO2 concentration equal or greater than 25 mEq/l (group B) and then both groups were compared for the following parameters: protein catabolic rate, dietary protein intake by dietary history, Kt/V, serum albumin, weight, pre-dialysis serum creatinine and pre-dialysis BUN. Patients from group A had a significantly lower age, a significantly higher protein catabolic rate and significantly higher values for pre-dialysis serum creatinine and BUN. The values for body weight, dietary protein intake and serum albumin were also higher in group A than in group B but the differences did not reach statistical significance. There was a good correlation between protein catabolic rate and pre-dialysis total CO2 and between the latter and serum albumin. These results suggest that moderately low pre-dialysis serum bicarbonate concentration is usually the result of high protein intake and should be of no concern in well-dialyzed patients with a protein catabolic rate greater than 1 g/kg/day. However, further studies are needed to confirm this conclusion.

MeSH terms

  • Acidosis / blood
  • Acidosis / metabolism
  • Acidosis / physiopathology*
  • Adult
  • Aged
  • Blood Urea Nitrogen
  • Carbon Dioxide / blood
  • Creatinine / blood
  • Humans
  • Middle Aged
  • Proteins / metabolism*
  • Renal Dialysis
  • Serum Albumin / analysis


  • Proteins
  • Serum Albumin
  • Carbon Dioxide
  • Creatinine