Subcapsular cell hyperplasia and mast cell infiltration in the adrenal cortex of mice: comparative study in 7 inbred strains

Exp Anim. 1997 Oct;46(4):303-6. doi: 10.1538/expanim.46.303.


Subcapsular cell hyperplasia (SCH) in the adrenal cortex of aged mice (13-15 months old) was frequent in both sexes of BALB/c, C3H/He, DBA/2J and IQI/Jic mice and in the females of A/J and C57BL/6, although the incidence and severity of SCH were considerably different among mouse strains. Mast cells were closely associated with SCH in the A/J, BALB/c, C57BL/6, DBA/2J and IQI/Jic mice, but not in the C3H/He strain. Compared with other strains, IQI/Jic mice had a significantly larger number of mast cells in the adrenal glands. Our findings suggest that mast cells may participate in the development of SCH, and IQI/Jic would be suitable for studying the pathogenesis of SCH and the role of mast cells in this lesion.

Publication types

  • Comparative Study

MeSH terms

  • Adrenal Cortex Diseases / etiology
  • Adrenal Cortex Diseases / pathology
  • Adrenal Cortex Diseases / veterinary*
  • Adrenal Glands / cytology
  • Adrenal Glands / pathology*
  • Animals
  • Female
  • Hyperplasia / etiology
  • Male
  • Mast Cells / physiology*
  • Mice
  • Mice, Inbred Strains / anatomy & histology*