Molecular basis of antimicrobial resistance in non-typable Haemophilus influenzae

Microbiologia. 1997 Sep;13(3):309-14.


Strains of the facultative anaerobe Haemophilus influenzae, both type b and non typable strains, are frequently multiresistant. The measurement of the antibiotic permeability of Haemophilus influenzae outer membrane (OM) shows that antibiotics can cross through the OM easily. Thus, enzymatic activity or efflux pumps could be responsible for multiresistance. An efflux system closely related to AcrAB of Escherichia coli is present in Haemophilus influenzae. However, their role in multiresistance seems irrelevant. Classical mechanisms such as plasmid exchange seems to be playing a major role in the multidrug resistance in Haemophilus influenzae.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / metabolism
  • Bacterial Outer Membrane Proteins / physiology
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology
  • Biological Transport
  • Biological Transport, Active
  • Carrier Proteins*
  • Cell Membrane Permeability
  • Drug Resistance, Microbial / genetics
  • Drug Resistance, Microbial / physiology*
  • Drug Resistance, Multiple / genetics
  • Drug Resistance, Multiple / physiology*
  • Escherichia coli Proteins*
  • Haemophilus influenzae / drug effects*
  • Haemophilus influenzae / genetics
  • Haemophilus influenzae / physiology
  • Lipoproteins / genetics
  • Lipoproteins / physiology
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Membrane Transport Proteins
  • Multidrug Resistance-Associated Proteins
  • R Factors


  • AcrA protein, E coli
  • AcrB protein, E coli
  • Anti-Bacterial Agents
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Carrier Proteins
  • Escherichia coli Proteins
  • Lipoproteins
  • Membrane Proteins
  • Membrane Transport Proteins
  • Multidrug Resistance-Associated Proteins