gamma-Tocopherol: an efficient protector of lipids against nitric oxide-initiated peroxidative damage

Nutr Rev. 1997 Oct;55(10):376-8. doi: 10.1111/j.1753-4887.1997.tb01566.x.

Abstract

Nitric oxide released by macrophages during inflammation reacts with active oxygen to form peroxynitrite. Peroxynitrite nitrates protein and peroxidizes lipids. gamma-Tocopherol traps peroxynitrite and is more effective than alpha-tocopherol in protecting lipids against such peroxidation.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Humans
  • Lipid Peroxidation / drug effects*
  • Macrophages / metabolism
  • Nitrates / chemistry
  • Nitrates / pharmacology
  • Nitric Oxide / pharmacology*
  • Vitamin E / pharmacology*

Substances

  • Nitrates
  • Vitamin E
  • peroxynitric acid
  • Nitric Oxide