Switching gears during T-cell maturation: RANTES and late transcription

Immunol Today. 1997 Oct;18(10):468-71. doi: 10.1016/s0167-5699(97)01128-6.


Although much is understood about the induction of genes expressed early (within 24 h) after T-cell activation, little is known about the regulation of expression of genes expressed 'late' (three or more days) post-stimulation. A better understanding of transcriptional regulation at this important stage of T-cell maturation may yield new insights into T-cell development and new immunotherapeutic targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Chemokine CCL5 / genetics*
  • Humans
  • Immunotherapy
  • Lymphocyte Activation / genetics
  • Promoter Regions, Genetic
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism
  • Time Factors
  • Transcription Factors / metabolism
  • Transcription, Genetic


  • Chemokine CCL5
  • Transcription Factors