Speed congenics: a classic technique in the fast lane (relatively speaking)

Immunol Today. 1997 Oct;18(10):472-7. doi: 10.1016/s0167-5699(97)01126-2.

Abstract

Marker-assisted selection protocol (MASP)-based strategies produce congenic strains with the target gene contained on clearly defined donor-derived genomic intervals in less than half the member of generations required by the classic protocol. Thus, the quality and speed of congenic strain construction are enhanced by this methodology. Here, Edward Wakeland and colleagues compare various MASP-based strategies and discuss their advantages with reference to immunological traits.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Computer Simulation
  • Crosses, Genetic
  • Female
  • Genetic Markers
  • Genetic Techniques*
  • Immunogenetics*
  • Male
  • Mice
  • Mice, Transgenic

Substances

  • Genetic Markers