The host-tumor immune conflict: from immunosuppression to resistance and destruction

Immunol Today. 1997 Oct;18(10):493-7. doi: 10.1016/s0167-5699(97)01115-8.


A successful immune response against a tumor is dependent on the cytokine repertoire present at the tumor site. Salem Chouaib and colleagues discuss evidence that, to escape the immune system, tumor cells not only produce immunosuppressive cytokines but also employ strategies involving altered susceptibility to tumor necrosis factor and Fas cytotoxic pathways and, in some circumstances, use of the Fas ligand to neutralize effector cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Cytokines / immunology
  • Fas Ligand Protein
  • Growth Substances / immunology
  • Humans
  • Immune Tolerance
  • Membrane Glycoproteins / immunology
  • Neoplasms / immunology*
  • T-Lymphocytes, Cytotoxic / immunology


  • Cytokines
  • FASLG protein, human
  • Fas Ligand Protein
  • Growth Substances
  • Membrane Glycoproteins