Effects of exercise in diabetic rats before and during gestation on maternal and neonatal outcomes

Am J Physiol. 1997 Oct;273(4):E727-33. doi: 10.1152/ajpendo.1997.273.4.E727.

Abstract

This study was designed to evaluate the effects of chronic endurance training on glucose and lipid homeostasis in diabetic mothers and their offspring. Female Sprague-Dawley rats were rendered diabetic (>20 mmol/l glucose) by streptozotocin and subdivided into three treatments (n = 10/group): exercise (20 m/min; 0% grade; 1 h/day; 5 days/wk) before and during gestation (EE), exercise before gestation with cessation on conception (ES), and sedentary before and during gestation (SS). Response of dams to a preconception and third trimester glucose tolerance test, litter number (EE = ES = SS = 3), and average litter size (EE = 9.7 +/- 1.5; ES = 9.0 +/- 1.5; SS = 8.3 +/- 0.3) did not differ among groups. Number of offspring remaining viable was significantly different among groups (EE = 17; ES = 0; SS = 14). Response to a glucose challenge and fasting glucose and insulin were different between the EE and SS pups. Exercise before and during gestation did not reduce the viability of offspring. Cessation of exercise during early pregnancy negatively affected offspring viability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Body Weight
  • Cholesterol / blood
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / physiopathology*
  • Female
  • Fetal Resorption
  • Glucose Tolerance Test
  • Homeostasis
  • Insulin / blood
  • Litter Size
  • Male
  • Physical Conditioning, Animal / physiology*
  • Pregnancy
  • Pregnancy Outcome*
  • Pregnancy in Diabetics / blood
  • Pregnancy in Diabetics / physiopathology*
  • Rats
  • Rats, Sprague-Dawley
  • Sex Ratio

Substances

  • Blood Glucose
  • Insulin
  • Cholesterol