Chronic granulomatous disease masquerading as a bladder tumor: a potential source of diagnostic error

Eur Urol. 1997;32(3):380-4.


Chronic granulomatous disease (CGD) is a rare inherited disease of childhood, characterized by recurrent bacterial or fungal infections. The underlying defect is a dysfunction of neutrophil granulocytes interfering with their ability to kill phagocytosed microorganisms. Genitourinary tract involvement has been reported in 38% of these patients. We report a case of CGD in whom the most important findings were urinary bladder tumors at different locations and a subsequent obstruction of the left ureter. A review of the pathogenesis of the disease, potential involvement of the urinary tract and treatment is presented.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cystoscopy
  • Diagnosis, Differential
  • Granulomatous Disease, Chronic / complications
  • Granulomatous Disease, Chronic / diagnosis*
  • Granulomatous Disease, Chronic / diagnostic imaging
  • Granulomatous Disease, Chronic / pathology
  • Humans
  • Hydronephrosis / etiology
  • Magnetic Resonance Imaging
  • Male
  • Mucous Membrane / pathology
  • Polyps / diagnosis*
  • Polyps / diagnostic imaging
  • Polyps / pathology
  • Ultrasonography
  • Ureter / pathology
  • Urinary Bladder Neoplasms / diagnosis*
  • Urinary Bladder Neoplasms / diagnostic imaging
  • Urinary Bladder Neoplasms / pathology