Benztropine abuse and overdose--case report and review

Adverse Drug React Toxicol Rev. 1997 Jun;16(2):103-12.


The abuse and overdose of anti-cholinergic agents such as benztropine is well reported in the psychiatric and emergency medicine journals. However, despite almost 40 years since the first modern report, physicians in general remain poorly aware of anti-cholinergic abuse. A case report of recreational overdose of benztropine in a 19 year old schizophrenic patient is presented. Delirium and anti-cholinergic manifestations persisted for five days necessitating prolonged hospitalization. The literature on benztropine abuse and overdose is reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Benztropine / adverse effects*
  • Drug Overdose / etiology
  • Drug Overdose / therapy
  • Humans
  • Male
  • Muscarinic Antagonists / adverse effects*
  • Substance-Related Disorders*


  • Muscarinic Antagonists
  • Benztropine