A novel RNA-binding motif in influenza A virus non-structural protein 1

Nat Struct Biol. 1997 Nov;4(11):891-5. doi: 10.1038/nsb1197-891.


The solution NMR structure of the RNA-binding domain from influenza virus non-structural protein 1 exhibits a novel dimeric six-helical protein fold. Distributions of basic residues and conserved salt bridges of dimeric NS1(1-73) suggest that the face containing antiparallel helices 2 and 2' forms a novel arginine-rich nucleic acid binding motif.

Publication types

  • Letter
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Binding Sites
  • Dimerization
  • Influenza A virus / chemistry*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Protein Structure, Secondary
  • RNA / metabolism*
  • Viral Nonstructural Proteins / chemistry*
  • Viral Nonstructural Proteins / metabolism


  • INS1 protein, influenza virus
  • Viral Nonstructural Proteins
  • RNA