C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site

Nat Struct Biol. 1997 Nov;4(11):900-3. doi: 10.1038/nsb1197-900.


The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Crystallography, X-Ray
  • DNA, Single-Stranded / metabolism*
  • Dimerization
  • Humans
  • Immediate-Early Proteins
  • Membrane Proteins
  • Models, Molecular
  • Molecular Sequence Data
  • Repressor Proteins*
  • Trans-Activators / chemistry*


  • DNA, Single-Stranded
  • IFRD2 protein, human
  • Immediate-Early Proteins
  • Membrane Proteins
  • Repressor Proteins
  • Trans-Activators