Methotrexate use in psoriasis and psoriatic arthritis

Rheum Dis Clin North Am. 1997 Nov;23(4):797-809. doi: 10.1016/s0889-857x(05)70361-6.


Methotrexate is an extremely effective drug in the treatment of psoriasis and psoriatic arthritis. In addition, it possesses a very high benefit-to-toxicity ratio compared with other therapies and immunosuppressive agents used in these disorders. Fortunately, most adverse events related to methotrexate are mild, but serious and life-threatening reactions, particularly liver toxicity, may occur. Careful monitoring is essential to prevent most undesirable side effects.

Publication types

  • Review

MeSH terms

  • Antirheumatic Agents / adverse effects
  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Psoriatic / drug therapy*
  • Drug Monitoring
  • Humans
  • Liver / drug effects
  • Liver / pathology
  • Liver Cirrhosis / chemically induced
  • Liver Cirrhosis / pathology
  • Methotrexate / adverse effects
  • Methotrexate / therapeutic use*
  • Psoriasis / drug therapy*


  • Antirheumatic Agents
  • Methotrexate