Influence of a blend of fructo-oligosaccharides and sugar beet fiber on nutrient digestibility and plasma metabolite concentrations in healthy beagles

Am J Vet Res. 1997 Nov;58(11):1238-42.

Abstract

Objective: To evaluate effects of a blend of fructo-oligosaccharides and sugar beet fiber (4:1) at 3 incorporation rates on nutrient digestibility and plasma glucose, insulin, alpha-aminonitrogen, urea, cholesterol, and triglycerides concentrations measured weekly in nonfed dogs and during a 360-minute period after a meal.

Animals: 8 castrated 1- to 1.4-year-old young adult male Beagles weighing 10.0 to 13.5 kg.

Procedure: Diets containing 2 incorporation rates of a blend of fructo-oligosaccharides and sugar beet fiber (5 and 10% on a dry matter basis [diets B and C, respectively]) were compared with a control diet without additional fiber (diet A). The 3 diets were evaluated for ability to modify digestibility of dry and organic matter, protein, fat, and ash and for effects on plasma glucose, insulin, alpha-aminonitrogen, urea, cholesterol, and triglycerides concentrations. Each diet was fed for 6 weeks; plasma samples were collected weekly before feeding and after feeding on the last day of the period. During 1 week at the end of the 6-week period, dogs were kept in metabolic cages. Each period of the block was followed by a 4-week washout period.

Results: Incorporating the blend of fructo-oligosaccharides and sugar beet fiber in the diet was associated with greater passage of wet feces (diets B and C) and lower protein digestibility (diet C). Postprandial glucose (diet C), urea (diets B and C) and triglyceride (diets B and C) concentrations were significantly (P < 0.01) decreased. Weekly preprandial measurements were characterized by decreased urea (diets B and C), cholesterol (diet C), and triglycerides (diets B and C) concentrations (P < 0.001).

Conclusion: Chronic consumption of fermentable fiber is associated with mildly decreased protein digestibility and with metabolic effects in nonfed or fed dogs.

Clinical relevance: A blend of fructo-oligosaccharides and sugar beet fiber should be tested as a dietary aid for treatment of chronic diseases, such as diabetes mellitus or hyperlipidemia, in dogs.

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Body Weight / drug effects
  • Body Weight / physiology
  • Chenopodiaceae / chemistry*
  • Cholesterol / blood
  • Diet / veterinary
  • Dietary Fats / metabolism
  • Dietary Fiber / analysis
  • Dietary Fiber / metabolism
  • Dietary Fiber / pharmacology*
  • Dietary Proteins / metabolism
  • Digestion / drug effects*
  • Dogs / blood
  • Dogs / physiology*
  • Fructose / pharmacology*
  • Insulin / blood
  • Male
  • Oligosaccharides / pharmacology*
  • Random Allocation
  • Time Factors
  • Triglycerides / blood
  • Urea / blood

Substances

  • Blood Glucose
  • Dietary Fats
  • Dietary Fiber
  • Dietary Proteins
  • Insulin
  • Oligosaccharides
  • Triglycerides
  • Fructose
  • Urea
  • Cholesterol