Pathogenesis and host defense in pulmonary infections

Curr Opin Pulm Med. 1995 May;1(3):163-70.


The development of pneumonia typically results from an overwhelming bacterial inoculum or a breakdown in the integrity of the host's pulmonary defense mechanisms. Augmentation of pulmonary defenses is one means of reducing the incidence, morbidity, and mortality from pneumonia. Strategies to enhance pulmonary or systemic defenses are actively being investigated. Selected established and investigational measures enhancing host defense mechanisms against various pathogens are reviewed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Humans
  • Lung / immunology
  • Pneumonia, Bacterial* / etiology
  • Pneumonia, Bacterial* / immunology
  • Pneumonia, Bacterial* / prevention & control
  • Systemic Inflammatory Response Syndrome / immunology