T cell activation in vivo by dengue virus infection

J Clin Lab Immunol. 1995;46(1):35-40.


It is accepted that T cells play a critical role during virus infections; however, T cell responses in vivo in acute stage of virus infection are not understood. We examined T cell activation in vivo in two volunteers who developed dengue fever in response to vaccination with a candidate live dengue vaccine. Serial plasma collected from the volunteers from day 0 (before infection) to day 17 after infection were examined for levels of soluble interleukin-2 receptor (sIL-2R), soluble CD4 (sCD4), soluble CD8 (sCD8), interleukin-2 (IL-2) and interferon gamma (INF gamma). Elevation of the levels of sIL-2R, IFN gamma, sCD4 and IL-2 became obvious during the period of viremia and was followed by a later increase in the level of sCD8. The levels of IFN gamma and sIL-2R declined after the end of the period of viremia. These results indicate that i. T cells are activated in vivo by dengue virus infection ii. activation of CD4+ T cells occurs during the period of viremia iii. activation of CD8+ T cells follows CD4+ T cell activation. These results suggest that activation of T cells in vivo may contribute to controlling acute dengue virus infections.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • CD4 Antigens / blood
  • CD4-Positive T-Lymphocytes / immunology
  • CD8 Antigens / blood
  • CD8-Positive T-Lymphocytes / immunology
  • Dengue / etiology
  • Dengue / immunology*
  • Humans
  • Interferon-gamma / blood
  • Interleukin-2 / blood
  • Lymphocyte Activation*
  • Male
  • Receptors, Interleukin-2 / blood
  • Solubility
  • T-Lymphocytes / immunology*
  • Vaccines, Attenuated / adverse effects
  • Viral Vaccines / adverse effects
  • Viremia / immunology


  • CD4 Antigens
  • CD8 Antigens
  • Interleukin-2
  • Receptors, Interleukin-2
  • Vaccines, Attenuated
  • Viral Vaccines
  • Interferon-gamma