Hip and knee prostheses: evaluation of the natural history of periprosthetic bone changes

Semin Nucl Med. 1997 Oct;27(4):346-54. doi: 10.1016/s0001-2998(97)80007-4.


This is a review of normal adaptive bone remodeling in response to hip and knee endoprostheses as manifested by changes in regional bone mineral density and radiophosphate uptake as a function of time. The normal evolution of change may vary with the design and composition of the implant. Appreciation of the normal temporal alterations enhances the ability to disclose prosthetic complications, but it is not without its limitations. The literature reports on the efficacy of radiophosphate to detect implant loosening are variable and differ between those that are cemented and not.

Publication types

  • Review

MeSH terms

  • Absorptiometry, Photon
  • Bone Density*
  • Hip Joint / diagnostic imaging
  • Hip Prosthesis*
  • Humans
  • Knee Joint / diagnostic imaging
  • Knee Prosthesis*
  • Prosthesis Failure
  • Radionuclide Imaging
  • Technetium Tc 99m Medronate


  • Technetium Tc 99m Medronate