Enhanced Oral Bioavailability of Paclitaxel in Mice Treated With the P-glycoprotein Blocker SDZ PSC 833

Br J Cancer. 1997;76(9):1181-3. doi: 10.1038/bjc.1997.530.

Abstract

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
  • Administration, Oral
  • Animals
  • Biological Availability
  • Cyclosporins / administration & dosage*
  • Drug Combinations
  • Female
  • Mice
  • Mice, Inbred Strains
  • Paclitaxel / administration & dosage
  • Paclitaxel / blood
  • Paclitaxel / pharmacokinetics*
  • Time Factors

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Cyclosporins
  • Drug Combinations
  • Paclitaxel
  • valspodar