Laser's effect on bone and cartilage change induced by joint immobilization: an experiment with animal model

Lasers Surg Med. 1997;21(5):480-4. doi: 10.1002/(sici)1096-9101(1997)21:5<480::aid-lsm10>;2-d.


Objective: Influence of low-level (810 nm, Ga-Al-As semiconductor) laser on bone and cartilage during joint immobilization was examined with rats' knee model.

Materials and methods: The hind limbs of 42 young Wistar rats were operated on in order to immobilize the knee joint. One week after operation they were assigned to three groups; irradiance 3.9 W/cm2, 5.8 W/cm2, and sham treatment. After 6 times of treatment for another 2 weeks both hind legs were prepared for 1) indentation of the articular surface of the knee (stiffness and loss tangent), and for 2) dual energy X-ray absorptiometry (bone mineral density) of the focused regions.

Results and conclusions: The indentation test revealed preservation of articular cartilage stiffness with 3.9 and 5.8 W/cm2 therapy. Soft laser treatment has a possibility for prevention of biomechanical changes by immobilization.

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Bone Density / radiation effects
  • Bone Remodeling / radiation effects*
  • Cartilage, Articular / physiopathology*
  • Cartilage, Articular / radiation effects
  • Disease Models, Animal
  • Immobilization / adverse effects*
  • Joints / physiopathology*
  • Joints / radiation effects
  • Laser Therapy
  • Lasers*
  • Male
  • Radiotherapy Dosage
  • Rats
  • Rats, Wistar