Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase

Biochim Biophys Acta. 1997 Oct 11;1358(3):215-20. doi: 10.1016/s0167-4889(97)00089-x.

Abstract

Integrin-linked kinase (ILK) is a recently identified human protein kinase that has been implicated in integrin-mediated signal transduction and tumorigenesis. We have identified a mouse molecule that is highly homologous to human ILK. The mouse ILK homologue protein is readily recognized by antibodies raised against the human ILK protein, and the gene encoding the mouse ILK homologue is widely expressed in mouse tissues. The mouse ILK homologue gene has been mapped to chromosome 7E1 band. A second locus in the mouse chromosome 9E1-3 region has also been detected with a mouse ILK homologue cDNA probe by fluorescence in situ hybridization, suggesting the possible existence of an ILK pseudo-gene or a family of ILK genes in the mouse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibody Specificity
  • Base Sequence
  • Chromosome Mapping*
  • Humans
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Organ Specificity
  • Protein Kinases / chemistry*
  • Protein Kinases / genetics*
  • Protein Kinases / immunology
  • Protein-Serine-Threonine Kinases / chemistry*
  • Protein-Serine-Threonine Kinases / genetics*
  • Protein-Serine-Threonine Kinases / immunology
  • Recombinant Fusion Proteins / biosynthesis
  • Recombinant Fusion Proteins / chemistry
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid

Substances

  • Recombinant Fusion Proteins
  • Protein Kinases
  • integrin-linked kinase
  • Protein-Serine-Threonine Kinases

Associated data

  • GENBANK/U94479