Scanning slit confocal microscopy of fungal keratitis

Arch Ophthalmol. 1997 Nov;115(11):1461-3. doi: 10.1001/archopht.1997.01100160631019.


In vivo scanning slit confocal microscopy was performed in a patient with Fusarium solani keratitis. Morphologically distinctive abundant filamentous structures were observed intrastromally. Confocal microscopy of the culture plate growing F solani from the patient's corneal scraping revealed filaments morphologically similar to the filaments observed in vivo. After 1 week of medical therapy, subsequent confocal microscopy showed an increased load of filaments, supporting the decision to perform a penetrating keratoplasty. Confocal microscopy confirmed that all of the fungus was eradicated. This aided in the decision to administer corticosteroids and quickly discontinue antifungal agents.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antifungal Agents / therapeutic use
  • Corneal Stroma / microbiology
  • Corneal Stroma / pathology
  • Corneal Ulcer / diagnosis*
  • Corneal Ulcer / microbiology
  • Corneal Ulcer / therapy
  • Eye Infections, Fungal / diagnosis*
  • Eye Infections, Fungal / etiology
  • Eye Infections, Fungal / therapy
  • Fusarium / isolation & purification*
  • Humans
  • Keratoplasty, Penetrating
  • Male
  • Microscopy, Confocal / methods*
  • Mycoses / diagnosis*
  • Mycoses / etiology
  • Mycoses / therapy


  • Antifungal Agents