Histone synthesis in Trypanosoma cruzi

Exp Cell Res. 1997 Nov 1;236(2):446-52. doi: 10.1006/excr.1997.3749.


Trypanosoma cruzi is an ancient, parasitic eukaryote which does not undergo chromatin condensation during cell division. This behavior may be explained if one considers the strong amino acid sequence divergence of Trypanosoma histones compared to higher eukaryotes. In the latter organisms histone synthesis is coupled to DNA replication. Considering the nonconserved amino acid sequence of T. cruzi histones, as well as the absence of chromatin condensation in this organism, we have studied histone synthesis in relation to DNA replication in this parasite. We have found that core histones and a fraction of histone H1 are synthesized concomitantly to DNA replication. However, another fraction of histone H1 is constitutively synthesized.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arginine / metabolism
  • Cell Membrane Permeability
  • DNA Replication*
  • DNA, Protozoan / biosynthesis*
  • Histones / biosynthesis*
  • Lysine / metabolism
  • Resting Phase, Cell Cycle / physiology
  • Trypanosoma cruzi / metabolism*


  • DNA, Protozoan
  • Histones
  • Arginine
  • Lysine