Wegener's granulomatosis and ANCA syndromes

Neurol Clin. 1997 Nov;15(4):887-91. doi: 10.1016/s0733-8619(05)70353-4.


The nervous system is involved in approximately 25% of patients with classical Wegener's granulomatosis. The spectrum of this disease has been broadened with the discovery of the anti-neutrophil cytoplasmic antibodies, which are found in diseases sharing many clinical features. The ANCA testing may indicate a common mode of pathogenesis. The definitive diagnostic marker is histological, and that forms the best guide to specific therapy.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Alkylating Agents / therapeutic use
  • Anti-Infective Agents / therapeutic use
  • Antibodies, Antineutrophil Cytoplasmic / immunology*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Cyclophosphamide / therapeutic use
  • Granulomatosis with Polyangiitis / drug therapy
  • Granulomatosis with Polyangiitis / immunology*
  • Humans
  • Methotrexate / therapeutic use
  • Prognosis
  • Recurrence
  • Sulfamethoxazole / therapeutic use


  • Adrenal Cortex Hormones
  • Alkylating Agents
  • Anti-Infective Agents
  • Antibodies, Antineutrophil Cytoplasmic
  • Antimetabolites, Antineoplastic
  • Cyclophosphamide
  • Sulfamethoxazole
  • Methotrexate