The CD40 pathway in allograft rejection, acceptance, and tolerance

Curr Opin Immunol. 1997 Oct;9(5):641-7. doi: 10.1016/s0952-7915(97)80043-x.


The CD40 pathway plays a critical role at many levels of the sensitization and effector phases of allograft rejection. In addition to the important signaling role of this pathway for T cell help and effector function, recent evidence suggests that the CD40 pathway can directly co-stimulate T cells, independently of its effect on the B7-CD28 pathway.

Publication types

  • Review

MeSH terms

  • CD40 Antigens*
  • Graft Rejection*
  • Graft Survival*
  • Humans
  • Immune Tolerance
  • Organ Transplantation*
  • Signal Transduction
  • Transplantation, Homologous


  • CD40 Antigens