Minor histocompatibility antigens

Curr Opin Immunol. 1997 Oct;9(5):655-61. doi: 10.1016/s0952-7915(97)80045-3.


The existence of transplantation antigens, in addition to those encoded by genes in the MHC, has been known for over half a century. The molecular identification of these additional minor histocompatibility (H) antigens lagged behind that of their MHC counterparts, largely because minor H antigens are recognised by T cells and not by antibodies. In the past year, however, new minor H antigens have been identified at both the genetic and protein level and include Uty, a second novel gene encoding a male-specific epitope in mice, a novel autosomal gene encoding each of the H-13 alleles of mice, and a second male-specific epitope encoded by the SMCY gene.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Major Histocompatibility Complex / immunology
  • Mice
  • Minor Histocompatibility Antigens*
  • T-Lymphocytes / immunology


  • Minor Histocompatibility Antigens