HLA class I specific inhibitory receptors

Curr Opin Immunol. 1997 Oct;9(5):694-701. doi: 10.1016/s0952-7915(97)80051-9.


All human natural killer cells and some memory T cells express HLA class I receptors, so-called natural killer cell receptors (NKRs), a receptor class that in the past few years has been shown to include several members of the immunoglobulin superfamily and the C-type lectin CD94-NKG2A complex. NKR ligand mediated cross-linking leads to the recruitment and activation of a tyrosine phosphatase involved in downregulating the phosphorylation of effector molecules involved in cell triggering. Thus, NKR engagement leads to the inhibition of different NK and T cell functions.

Publication types

  • Review

MeSH terms

  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Immunologic Memory*
  • Killer Cells, Natural / immunology*
  • Receptors, Immunologic*


  • Histocompatibility Antigens Class I
  • Receptors, Immunologic