Glyceryl trinitrate vs. sphincterotomy for treatment of chronic fissure-in-ano: a randomized, controlled trial

Dis Colon Rectum. 1997 Nov;40(11):1318-20. doi: 10.1007/BF02050816.


Purpose: This study was undertaken to compare local application of a glyceryl trinitrate ointment with lateral internal sphincterotomy for the treatment of chronic fissure-in-ano.

Patients and methods: A sample of 24 consecutive patients with chronic anal fissure was randomly allocated to treatment with sphincterotomy or local glyceryl trinitrate. Patients were followed-up for a median of 22 months.

Results: All 12 patients healed following sphincterotomy; 10 of 12 healed with local glyceryl trinitrate (P = 0.239). There were no recurrences or side-effects in either group.

Conclusions: Local application of glyceryl trinitrate can avoid surgery in more than 80 percent of patients with chronic anal fissure.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Anal Canal / surgery*
  • Chronic Disease
  • Female
  • Fissure in Ano / therapy*
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Nitroglycerin / administration & dosage*
  • Ointments


  • Ointments
  • Nitroglycerin