Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA

Bioorg Med Chem. 1997 Oct;5(10):1925-34. doi: 10.1016/s0968-0896(97)00130-2.


Distinct differences in in vivo stability of the two diastereomeric C-Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo.

MeSH terms

  • Animals
  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry*
  • Chelating Agents / pharmacokinetics
  • Drug Stability
  • Humans
  • Isothiocyanates / chemical synthesis*
  • Isothiocyanates / chemistry*
  • Ligands
  • Mice
  • Pentetic Acid / analogs & derivatives*
  • Pentetic Acid / chemical synthesis
  • Pentetic Acid / chemistry*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tissue Distribution
  • Yttrium / chemistry


  • Chelating Agents
  • Isothiocyanates
  • Ligands
  • N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid
  • Yttrium
  • Pentetic Acid