Chemopreventive effects of sandalwood oil on skin papillomas in mice

Eur J Cancer Prev. 1997 Aug;6(4):399-401. doi: 10.1097/00008469-199708000-00013.

Abstract

The essential oil, emulsion or paste of sandalwood (Santalum album L) has been used in India as an ayurvedic medicinal agent for the treatment of inflammatory and eruptive skin diseases. In this investigation, the chemopreventive effects of sandalwood oil (5% in acetone, w/v) on 7,12-dimethylbenz(a)anthracene-(DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate(TPA)-promoted skin papillomas, and TPA-induced ornithine decarboxylase (ODC) activity in CD1 mice were studied. Sandalwood oil treatment significantly decreased papilloma incidence by 67%, multiplicity by 96%, and TPA-induced ODC activity by 70%. This oil could be an effective chemopreventive agent against skin cancer.

Publication types

  • Comparative Study

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Chemoprevention
  • Chi-Square Distribution
  • Coumarins / therapeutic use*
  • Disease Models, Animal
  • Incidence
  • Mice
  • Mice, Inbred Strains
  • Odds Ratio
  • Ornithine Decarboxylase / metabolism*
  • Papilloma / chemically induced
  • Papilloma / epidemiology
  • Papilloma / prevention & control*
  • Plant Oils / therapeutic use*
  • Reference Values
  • Sesquiterpenes / therapeutic use*
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / prevention & control*
  • Survival Rate

Substances

  • Coumarins
  • Plant Oils
  • Sesquiterpenes
  • 9,10-Dimethyl-1,2-benzanthracene
  • Ornithine Decarboxylase
  • sandalwood oil