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Comparative Study
. 1997 Nov;41(11):2540-3.

Differential Selection of Multidrug Efflux Systems by Quinolones in Pseudomonas Aeruginosa

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Free PMC article
Comparative Study

Differential Selection of Multidrug Efflux Systems by Quinolones in Pseudomonas Aeruginosa

T Köhler et al. Antimicrob Agents Chemother. .
Free PMC article

Abstract

Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.

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