Influence of dobutamine on hemodynamics and coronary blood flow in patients with and without coronary artery disease

Am J Cardiol. 1976 Jul;38(1):103-8. doi: 10.1016/0002-9149(76)90070-9.


The influence of dobutamine on hemodynamics and coronary blood flow was studied in patients after routine cardiac catheterization. The data demonstrated that dobutamine is a powerful inotropic agent at a dose that has a relatively small influence on heart rate. In patients without coronary artery disease dobutamine greatly increased coronary arterial perfusion. In patients with severe coronary artery diseases dobutamine resulted in a much smaller increase in coronary perfusion, and the pattern of perfusion became more inhomogeneous. The results suggest that dobutamine has a potential inotropic value but raise concern about its influence on regional myocardial perfusion in patients with serious coronary artery disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Pressure / drug effects
  • Cardiac Output / drug effects
  • Catecholamines / therapeutic use*
  • Coronary Circulation / drug effects*
  • Coronary Disease / drug therapy*
  • Dobutamine / therapeutic use*
  • Drug Evaluation
  • Female
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Humans
  • Male
  • Middle Aged
  • Myocardial Contraction / drug effects


  • Catecholamines
  • Dobutamine