Calcium and Signal Transduction in Granulocytes

Curr Opin Hematol. 1996 Jan;3(1):63-70. doi: 10.1097/00062752-199603010-00010.

Abstract

During activation, blood cells experience changes in intracellular free calcium levels ([Ca2+]i) that are associated with signal transduction events. In granulocytic cells, changes in [Ca2+]i have been associated with multiple functions, including activation of cellular kinases and phosphatases, degranulation, phagosome-lysosome fusion, regulation of cytoskeletal binding proteins, transcriptional control, and modulation of surface receptors. This review discusses the general role played by [Ca2+]i in granulocytic leukocyte signal transduction, with a special emphasis on recent developments in the field of calcium signaling to and from integrins and the regulation of cell adhesion and motility by [Ca2+]i.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Calcium / metabolism
  • Calcium / physiology*
  • Cell Movement
  • Granulocytes / physiology*
  • Integrins / metabolism
  • Phosphoric Monoester Hydrolases / physiology
  • Receptors, Cell Surface / physiology
  • Signal Transduction*

Substances

  • Integrins
  • Receptors, Cell Surface
  • Phosphoric Monoester Hydrolases
  • Calcium