Functional organization of cotransmission systems: lessons from small nervous systems

Invert Neurosci. 1995;1(2):105-12. doi: 10.1007/BF02331908.


Small invertebrate nervous systems allow one to ask a series of questions concerning the functional roles of cotransmitters. This review outlines some of the implications of cotransmission for target selectivity in complex neuropils. We suggest the possibility that a unique constellation of cotransmitters in individual identified modulatory neurons allows a specificity of action even when peptides may act over an extended distance, and when individual modulatory substances may be released from several modulatory neurons.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Invertebrates / physiology*
  • Nervous System Physiological Phenomena*
  • Neurotransmitter Agents / physiology
  • Synaptic Transmission / physiology*
  • Tissue Distribution


  • Neurotransmitter Agents