Peripheral multifocal chorioretinitis: a distinct clinical entity?

Ophthalmology. 1997 Nov;104(11):1820-6. doi: 10.1016/s0161-6420(97)30021-9.


Objective: The purpose of the study is to delineate the clinical features, complications, visual prognosis, and associated systemic diseases of peripheral multifocal chorioretinitis.

Design: The study design was a retrospective study.

Participants: Of 828 patients with uveitis, 53 patients (6.4%) fulfilled all 3 of the following criteria: (1) the presence of multiple (>10), small, round, punched-out lesions in the peripheral retina; (2) the absence of central chorioretinal lesions; and (3) an associated intraocular inflammatory reaction.

Results: The majority of patients were elderly white females with bilateral ocular involvement. The presenting symptoms consisted of vitreitis and/or iritis, papillitis, and numerous retinal punched-out lesions in the periphery. On initial examination, the complications included cystoid macular edema (CME) (48%), glaucoma (25%), and cataracts (19%), resulting in a mean visual acuity of 20/80. After more than 2 years of follow-up, CME was found in 72% and cataract in 62% of the affected eyes. Submacular neovascularization never developed. The final mean visual acuity was 20/60; this was mainly dependent on the presence of CME (eyes with CME; visual acuity was 20/80, eyes without CME; visual acuity was 20/50). In 25% of patients, an association with sarcoidosis was observed (histologic and radiologic diagnoses), and an additional 29% of patients had elevated serum angiotensin-converting enzyme levels.

Conclusions: Within the spectrum of multifocal chorioretinitis, the authors have defined a distinct clinical entity of peripheral multifocal chorioretinitis. The recognition of this clinical entity may be valuable because of its specific symptoms, prognosis, and association with sarcoidosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cataract / etiology
  • Cataract / physiopathology
  • Child
  • Chorioretinitis / complications
  • Chorioretinitis / pathology*
  • Chorioretinitis / physiopathology
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Glaucoma / etiology
  • Glaucoma / physiopathology
  • Humans
  • Macular Edema / etiology
  • Macular Edema / physiopathology
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Vision Disorders / etiology
  • Vision Disorders / physiopathology
  • Visual Acuity / physiology