Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene

Gene. 1997 Oct 24;200(1-2):177-83. doi: 10.1016/s0378-1119(97)00415-0.


We have mapped the human ORFX gene to chromosome 9q34 and determined its complete gene structure. Comparison with RING3, the human MHC-linked homologue on 6p21.3, shows the two gene structures to be highly conserved but with an approximate threefold expansion in the ORFX introns. RING3 and ORFX are found to be ubiquitously expressed in human adult and foetal tissues. Evidence suggests that the two genes may have arisen from an ancient duplication in a common ancestral chromosome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Base Sequence
  • Binding Sites
  • Cells, Cultured
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6*
  • Chromosomes, Human, Pair 9*
  • Consensus Sequence
  • Conserved Sequence
  • Fetus
  • Genetic Linkage
  • Humans
  • In Situ Hybridization, Fluorescence
  • Introns
  • Major Histocompatibility Complex*
  • NF-kappa B / metabolism
  • Protein Serine-Threonine Kinases / biosynthesis*
  • Protein Serine-Threonine Kinases / genetics*
  • RNA-Binding Proteins / biosynthesis*
  • RNA-Binding Proteins / genetics*
  • Transcription Factors
  • Transcription, Genetic*


  • BRD2 protein, human
  • BRD3 protein, human
  • NF-kappa B
  • RNA-Binding Proteins
  • Transcription Factors
  • Protein Serine-Threonine Kinases