CD59: its role in complement regulation and potential for therapeutic use

Immunotechnology. 1995 Dec;1(3-4):157-68. doi: 10.1016/1380-2933(95)00018-6.


CD59 regulates complement activation cascade at the final step, inhibiting formation of membrane attack complex (MAC). This protein, being anchored to the cell membrane via glycosyl phosphatidyl inositol (GPI), is expressed ubiquitously on cells which are in contact with body fluids containing components. Recently, MAC formation has been reported to play an important role in pathogenesis of inflammatory diseases such as ischemia or autoimmune diseases. In this review, we describe the structure and biological activities of CD59, the pathogenic role of MAC formation, and discuss application of soluble molecules of CD59 for therapeutic use.

Publication types

  • Review

MeSH terms

  • Animals
  • CD59 Antigens / physiology*
  • CD59 Antigens / therapeutic use
  • Complement Activation / physiology*
  • Humans


  • CD59 Antigens